Search results for "Carbazoquinocin C"

showing 3 items of 3 documents

Synthesis and biological evaluation of structural variants of carbazoquinocin C

2003

Some new structural variants of the alkaloid carbazoquinocin C were synthesized in a few steps with good to excellent yields. The key step comprises a cyclisation reaction of appropriate 2-vinylindoles with oxalyl chloride. The carbazole-3,4-quinones are able to trap oxygen-centred radicals. In some biological/biochemical assays some of these compounds exhibit extraordinary results including inhibition of cyclooxygenase-1 and 5-lipoxygenase in the μM-range. Moreover some of the carbazoquinocin C-variants inhibit significant oxidative damage of cellular DNA in nM-range.

Oxidative damagechemistry.chemical_compoundOxalyl chloridechemistryCellular dnaRadicalAlkaloidOrganic ChemistryCarbazoquinocin CCombinatorial chemistryBiological evaluationJournal of Heterocyclic Chemistry

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Synthesis and Biological Evaluation of Structural Variants of Carbazoquinocin C.

2003

StereochemistryChemistryCarbazoquinocin COrganic chemistryGeneral MedicineBiological evaluationChemInform

researchProduct

ChemInform Abstract: A New and Effective Method to Carbazoquinocin C and Related Carbazole-3,4-quinones as Biological Antioxidants: Key Reactions of …

2001

chemistry.chemical_compoundchemistryOxalyl chlorideCarbazoleCarbazoquinocin COrganic chemistryGeneral MedicineChemInform

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